赫斯1
前额叶皮质
社会失败
慢性应激
萧条(经济学)
下调和上调
内分泌学
内科学
重性抑郁障碍
Notch信号通路
心理学
生物标志物
神经科学
医学
生物
受体
基因
遗传学
扁桃形结构
认知
经济
宏观经济学
作者
Jiangfeng Liao,Gaofeng Zeng,Wenting Fang,Wanzhi Huang,Xiaoman Dai,Qinyong Ye,Jing Zhang,Xiaochun Chen
标识
DOI:10.1016/j.physbeh.2020.113197
摘要
The susceptibility to depression has been attributed to the chronic stress and genetic factors but still fails to identify definite biomarkers. The present study aimed to investigate the role of disrupted Notch signaling in the medial prefrontal cortex of the chronic social defeat stress (CSDS) mice and Wistar Kyoto (WKY) rats. RNA-sequencing and quantitative real-time PCR analyses evidenced the involvement of Notch signaling pathway in depression. Western blotting reported an increased level of Notch2 and NF-κB and a decreased level of Hes1 and Bcl2/Bax ratio both in the susceptible mice when compared with the control or resilient ones and in the depression WKY rats when compared with the Wistar or non-depression WKY groups. Further analysis showed that the above-mentioned changes were significantly correlated with the depression-like behaviors and that the elicited Notch2 strongly correlated with the upregulated NF-κB, not with the downregulated Hes1 or Bcl2/Bax ratio. In conclusion, the increased Notch2/NF-κB signaling in the medial prefrontal cortex may mediate depression susceptibility, providing a potential diagnostic biomarker or therapeutic target for treating major depressive disorder.
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