Two new steroidal alkaloids with cytotoxic activities from the roots of Veratrum grandiflorum Loes.

Two new steroidal alkaloids, Grandivine A and B (1 and 3), together with eight known related compounds were obtained from the roots of Veratrum grandiflorum Loes. The structures of the compounds were elucidated though extensive spectroscopic techniques. Compounds 3 and 4 exhibited moderate cytotoxic effects against four cancer cell lines.