后期
生物
细胞生物学
动细胞
着丝粒
有丝分裂
染色体分离
中期
主轴装置
遗传学
染色体
细胞分裂
基因
细胞
作者
Michael A. Hadders,Susanne M.A. Lens
标识
DOI:10.1016/j.tcb.2021.09.008
摘要
The Chromosomal Passenger Complex (CPC) regulates a plethora of processes during multiple stages of nuclear and cytoplasmic division. Early during mitosis, the CPC is recruited to centromeres and kinetochores, and ensures that the duplicated chromosomes become properly connected to microtubules from opposite poles of the mitotic spindle. Progression into anaphase is accompanied by a striking relocation of the CPC from centromeres to the antiparallel microtubule overlaps of the anaphase spindle and to the equatorial cortex. This translocation requires direct interactions of the CPC with the kinesin-6 family member MKLP2/KIF20A, and the inactivation of cyclin B-cyclin-dependent kinase-1 (CDK1). Here, we review recent progress in the regulation of this relocation event. Furthermore, we discuss why the CPC must be relocated during early anaphase in light of recent advances in the functions of the CPC post metaphase.
科研通智能强力驱动
Strongly Powered by AbleSci AI