苯并噻唑
化学
苯并咪唑
硫脲
抗菌剂
广告
组合化学
吲哚试验
药效团
尿素
质子核磁共振
氢键
对接(动物)
噻唑
抗菌活性
芳基
立体化学
有机化学
咪唑
喹唑啉
碳-13核磁共振
超分子化学
嘧啶
生物化学
体外
护理部
医学
作者
Ferruh Lafzi,Deryanur Kılıç,Melike Yildiz,Nurullah Saraçoğlu
标识
DOI:10.1016/j.molstruc.2021.130566
摘要
Urea/thiourea derivatives with heteroaromatic scaffolds such as indole, benzimidazole, and benzothiazole were designed, synthesized, and evaluated for their potential antimicrobial activity in vitro assays to establish against B. cereus, S. aureus, E. coli, and P. aeruginosa. Our results indicate that compounds are only active in gram-positive bacteria. Molecular docking studies were carried out for the most efficient compounds to understand the interactions with proteins involved in peptidoglycan synthesis. ADME calculations indicate that these compounds are more likely to be taken via the oral route. In summary, these findings may contribute to the design and development of candidates for more effective therapeutics in biological systems.
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