糖基化
炎症
免疫系统
平衡
生物
聚糖
细胞生物学
免疫学
糖蛋白
生物化学
作者
Jennifer C. Brazil,Charles A. Parkos
标识
DOI:10.1038/s41385-021-00466-8
摘要
Glycans are essential cellular components that facilitate a range of critical functions important for tissue development and mucosal homeostasis. Furthermore, specific alterations in glycosylation represent important diagnostic hallmarks of cancer that contribute to tumor cell dissociation, invasion, and metastasis. However, much less is known about how glycosylation contributes to the pathobiology of inflammatory mucosal diseases. Here we will review how epithelial and immune cell glycosylation regulates gut homeostasis and how inflammation-driven changes in glycosylation contribute to intestinal pathobiology.
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