微气泡
分子成像
间隙
对比度(视觉)
超声波
超声成像
分子探针
生物医学工程
医学
体内
纳米技术
材料科学
放射科
化学
计算机科学
生物
人工智能
泌尿科
生物技术
DNA
生物化学
作者
The Anh Nguyen,Jonathan R. Lindner
出处
期刊:Methods in molecular biology
日期:2022-01-01
卷期号:: 801-808
被引量:1
标识
DOI:10.1007/978-1-0716-1924-7_48
摘要
The management of cardiovascular conditions will likely be improved by noninvasive in vivo molecular imaging technologies that can provide earlier or more accurate diagnosis. These techniques are already having a positive impact in preclinical research by providing insight into disease pathobiology or efficacy of new therapies. Contrast enhanced ultrasound (CEU) molecular imaging is a technique that relies on the ultrasound detection of targeted microbubble contrast agents to examine molecular or cellular events that occur at the blood pool-endothelial interface. For the most part, targeted contrast agents are composed of encapsulated gas microbubbles (MBs) that are 2–4 μm in diameter, or other acoustically active micro- or nanoparticles. These agents bear several tens of thousands of binding molecules per particle. Because nonadhered agent is cleared rapidly, CEU molecular imaging can be performed in a matter of minutes. MBs are detected using contrast-specific techniques that generate and receive nonlinear signals produced by MB cavitation, thereby increasing signal-to-noise ratio. Dedicated kinetic models for molecular imaging have been generated that permit the elimination of signal from nonadherent agent.
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