甲壳素
化学
壳聚糖
伤口愈合
免疫系统
乙酰化
纳米技术
抗菌剂
计算生物学
生物
材料科学
生物化学
基因
免疫学
有机化学
作者
Shijie Gabriel Kou,Lin Peters,Michael R. Mucalo
标识
DOI:10.1016/j.carbpol.2022.119132
摘要
Chitosan has many desirable attributes e.g. antimicrobial properties and promoting wound healing, and is used in various applications. This article first discusses how degree of deacetylation (DD) and molecular weight (MW) impacts on what level of bioactivities chitosan manifests, then introduces the "molecular chain configuration" model to explain various possible mechanisms of antimicrobial interactions between chitosan with different MW and different types of bacteria. Similarly, the possible pathways of how chitosan reacts with cancer and the body's immune system to demonstrate immune and antitumor effects are also discussed by using this model. Moreover, the possible mechanisms of how chitosan enhances coagulation and wound healing are also discussed. With these beneficial bioactivities in mind, the application of chitosan in surgery, tissue engineering and oncology is outlined. This review concludes that as chitosan demonstrates many beneficial bioactivities via multiple mechanisms, it is an important polymer with a promising future in medicine.
科研通智能强力驱动
Strongly Powered by AbleSci AI