医学
鼻腔给药
重症监护医学
叙述性评论
疾病
干预(咨询)
生活质量(医疗保健)
免疫疗法
变应原免疫治疗
梅德林
儿科
过敏
医疗保健
慢性病
免疫学
哮喘
认知
慢性病
过敏原
疾病负担
基石
公共卫生
作者
Eleni Anastasiou,Paraskevi Xepapadaki,Julijana Asllani,Foteini Kapsouli,Aspasia Karavelia,Aikaterini Petta,Nikolaos G. Papadopoulos
摘要
Allergic rhinitis (AR) is the most common chronic condition from childhood to adulthood and remains a major, often underestimated, contributor to impaired quality of life, school performance, and healthcare use. Although symptoms frequently begin early in life, pediatric AR is still underdiagnosed and inadequately treated, with important consequences for physical, emotional, and cognitive development. In this narrative review, we summarize recent evidence on the treatment of AR in children, highlighting age-specific challenges and evolving treatment concepts. International recommendations, particularly those from ARIA, support a stepwise, patient-centred approach focused on symptom control, safety, and long-term outcomes. Intranasal corticosteroids remain the cornerstone of therapy for moderate-to-severe disease, while second-generation antihistamines and intranasal antihistamines provide effective options for milder or intermittent symptoms. Fixed-dose intranasal steroid-antihistamine combinations are highly effective, providing options for children with more severe or uncontrolled AR. Allergen immunotherapy is the only disease-modifying intervention. Emerging strategies, including biologics and novel immunotherapy approaches, are promising but currently limited to specific contexts. Alongside pharmacotherapy, education, adherence support, and pragmatic environmental measures are essential to achieve sustained disease control. Ongoing gaps in the pediatric evidence-base highlight the need for age-adapted algorithms and long-term studies focusing on early intervention and disease modification.
科研通智能强力驱动
Strongly Powered by AbleSci AI