Enzyme-Responsive Chemiluminescent Probes Assembled with Iridium(III) Photosensitizers via Host–Guest Chemistry for Chemiluminescence-Induced Photodynamic Therapy

) selectively generated ROS and elicited potent cytotoxicity in cancerous HeLa cells and spheroids under light-free conditions, with apoptosis as the predominant cell death pathway, while remaining noncytotoxic in normal HEK293 cells. This modular platform couples supramolecular host-guest assembly, enzyme-specific activation, and CRET-induced ROS generation to overcome the limitations of conventional PDT, enabling cancer-selective, light-free therapy.