2019年冠状病毒病(COVID-19)
脆弱性(计算)
荟萃分析
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)
2019-20冠状病毒爆发
医学
病毒学
重症监护医学
计算机科学
内科学
爆发
计算机安全
传染病(医学专业)
疾病
作者
Francesco Paolo Bianchi,Massimo Giotta,Andrea Martinelli,Maria Grazia Giurgola,Giulia Del Matto,Elita Mastrovito,M. C. Fedele,Giuseppe Manca,Salvatore Minniti,M. De Nuccio,Vincenzo Gigantelli,Silvio Tafuri,Stefano Termite
出处
期刊:Vaccines
[Multidisciplinary Digital Publishing Institute]
日期:2025-02-18
卷期号:13 (2): 203-203
标识
DOI:10.3390/vaccines13020203
摘要
Background: Splenectomized/asplenic individuals are at a heightened risk for severe infections due to compromised immune function. However, the impact of splenectomy/asplenia on COVID-19 outcomes remains underexplored. This study aims to systematically review and meta-analyze the association between splenectomy/asplenia and severe COVID-19 outcomes. Methods: Following the PRISMA guidelines, databases including Scopus, MEDLINE/PubMed, and Web of Knowledge were searched for relevant articles published between January 2020 and June 2024. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for severe COVID-19 outcomes, with a random-effects model being used to account for heterogeneity. Out of 749 identified studies, 4 met the inclusion criteria. Results: The meta-analysis revealed a significant association between splenectomy/asplenia and overall severe COVID-19 outcomes (OR = 1.92; 95% CI = 1.06–3.47). Specifically, splenectomy/asplenia was significantly associated with increased COVID-19-related hospitalization (OR = 2.06; 95% CI = 1.21–3.49), while the association with COVID-19-related death was not statistically significant (OR = 1.52; 95% CI = 0.78–2.99). COVID-19 vaccination is strongly recommended for these patients. Conclusions: Splenectomy/asplenia significantly increases the risk of severe COVID-19 outcomes, particularly hospitalization. The findings underscore the need for vigilant clinical management and targeted interventions for this vulnerable population. Further research is warranted to fully understand the risks and to develop effective guidelines for the protection of splenectomized individuals against COVID-19.
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