中性粒细胞胞外陷阱
血液肿瘤
细胞外
癌症研究
免疫学
医学
生物
内科学
炎症
细胞生物学
癌症
作者
Rongxing Liu,Jin Zhou,Fernando Lima,Jinhao Zeng,Qing Nian
标识
DOI:10.1016/j.biopha.2024.116334
摘要
Neutrophil extracellular traps (NETs) have emerged as a critical factor in malignant hematologic disease pathogenesis. These structures, comprising DNA, histones, and cytoplasmic proteins, were initially recognized for their role in immune defense against microbial threats. Growing evidence suggests that NETs contribute to malignant cell progression and dissemination, representing a double-edged sword. However, there is a paucity of reports on its involvement in hematological disorders. A comprehensive understanding of the intricate relationship between malignant cells and NETs is necessary to explore effective therapeutic strategies. This review highlights NET formation and mechanisms underlying disease pathogenesis. Moreover, we discuss recent advancements in targeted inhibitor development for selective NET disruption, empowering precise design and efficacious therapeutic interventions for malignant hematologic diseases.
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