蜕膜
免疫系统
生物
蜕膜化
免疫耐受
滋养层
螺旋动脉
免疫学
自然杀伤细胞
怀孕
淋巴细胞
人口
胎儿
细胞生物学
子宫内膜
医学
胎盘
内分泌学
细胞毒性T细胞
生物化学
遗传学
环境卫生
体外
作者
Fangfang Jin,Wei Liu,G. Cheng,Songchen Cai,Tailang Yin,Lianghui Diao
摘要
The role of decidual natural killer (dNK) cells in maintaining immune tolerance at the maternal-fetal interface during pregnancy is a significant topic in reproductive health. Immune tolerance is essential for a successful pregnancy and involves a complex immune response involving various immune cells and molecules. DNK cells comprise the largest population of lymphocyte subsets found in the decidua and play important roles in maintaining immune tolerance. These cells exert multiple functions to maintain homeostasis of the decidual microenvironment, including modulation of trophoblast invasion, promotion of fetal development, regulation of endometrial decidualization and spiral artery remodeling. DNK cells can also be divided into different subsets based on their functions as NKtolerant , NKcytotoxic , and NKregulatory cells. However, the relationship between dNK cells function and pregnancy outcomes is complex and poorly understood. In this review, we will focus on the physiological role of dNK cells during pregnancy and highlight the potential role in pathological pregnancies and therapeutic approaches.
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