工作流程
模块化设计
神经外科
软件部署
药物输送
医学
医学物理学
计算机科学
生物医学工程
外科
软件工程
数据库
操作系统
有机化学
化学
作者
Riccardo Secoli,Eloise Matheson,Marlene Pinzi,Stefano Galvan,Abdulhamit Donder,Thomas Watts,Marco Riva,Davide Danilo Zani,Lorenzo Bello,Ferdinando Rodriguez y Baena
出处
期刊:PLOS ONE
[Public Library of Science]
日期:2022-10-19
卷期号:17 (10): e0275686-e0275686
被引量:22
标识
DOI:10.1371/journal.pone.0275686
摘要
Over the past 10 years, minimally invasive surgery (MIS) has shown significant benefits compared to conventional surgical techniques, with reduced trauma, shorter hospital stays, and shorter patient recovery times. In neurosurgical MIS procedures, inserting a straight tool (e.g. catheter) is common practice in applications ranging from biopsy and laser ablation, to drug delivery and fluid evacuation. How to handle tissue deformation, target migration and access to deep-seated anatomical structures remain an open challenge, affecting both the preoperative planning phase and eventual surgical intervention. Here, we present the first neurosurgical platform in the literature, able to deliver an implantable steerable needle for a range of diagnostic and therapeutic applications, with a short-term focus on localised drug delivery. This work presents the system's architecture and first in vivo deployment with an optimised surgical workflow designed for pre-clinical trials with the ovine model, which demonstrate appropriate function and safe implantation.
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