免疫失调
免疫系统
单核细胞
损失函数
功能（生物学）
免疫学
细胞生物学
生物
表型
遗传学
基因
作者
Fang Yu,Satanay Hubrack,Christophe M. Raynaud,Asha Elmi,Rafah Mackeh,Nourhen Agrebi,Gaurav Thareja,Abdelaziz Belkadi,Hesham Al Saloos,Ayeda Abdulsalam Ahmed,Saleema C Purayil,Yasmin A. Mohamoud,Karsten Suhre,Charbel Abi Khalil,Frank Schmidt,Bernice Lo,Amel Hassan,Khaled Machaca
标识
DOI：10.1016/j.jaci.2024.02.026
摘要
TRPM4 is a broadly expressed, calcium-activated, monovalent cation channel that regulates immune cell function in mice and cell lines. Clinically, however, partial loss- or gain-of-function mutations in TRPM4 lead to arrhythmia and heart disease, with no documentation of immunologic disorders.
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