Potential molecular mechanism of Guiqi Baizhu Decoction in radiation-induced intestinal edema by regulating HIF-1a, AQP4 and Na+/K+-ATPase

Ionizing radiation (IR) can cause significant intestinal edema. AQP4 and Na⁺/K⁺-ATPase are the key factors of RIIE, which are regulated by ROS and HIF-1α. GQBZD can improve hypoxia and oxidative stress, regulate the expression of AQP4 and Na⁺/K⁺-ATPase, and achieve a protective effect on RIIE. This study is the first to reveal the mechanism of RIIE.