1.3.1 Enyne-Metathesis-Based Domino Reactions in Natural Product Synthesis

Enyne-metathesis-based domino processes are highlighted in the context of natural product synthesis; these include domino double ring-closing metathesis, enyne metathesis/metallotropic [1,3]-shifts, enyne metathesis/Diels–Alder reaction, and other variations of their domino combinations. Issues regarding selectivity and mechanism are also discussed.