Role of Histone Deacetylases (HDACs) in Epilepsy and Epileptogenesis

Background: Emerging evidence suggests that epigenetic mechanisms are involved in different brain functions such as the development of the nervous system and normal neuronal function. At the same time, it has been proposed that several neurological diseases are in part, caused by aberrant epigenetic modifications. Nevertheless, the mechanisms underlying pathological alterations in the brain genome are not completely understood. Keywords: Epigenetics, chromatin, histone deacetylase (HDAC), histone deacetylase inhibitors (HDACIs), epilepsy, epileptogenesis, brain disorders.