肺癌
癌症研究
医学
基因沉默
C5a受体
骨溶解
癌症
转移
骨转移
癌细胞
间质细胞
病理
免疫学
免疫系统
生物
补体系统
内科学
外科
基因
生物化学
作者
Daniel Ajona,Carolina Zandueta,Leticia Corrales,Haritz Moreno,María J. Pajares,Sergio Ortiz‐Espinosa,Elena Martínez‐Terroba,Naiara Perurena,Fernando J. de Miguel,Eloísa Jantus‐Lewintre,Carlos Camps,Silvestre Vicent,Jackeline Agorreta,Luis M. Montuenga,Rubén Pı́o,Fernando Lecanda
标识
DOI：10.1164/rccm.201703-0660oc
摘要
Disruption of C5aR1 signaling in lung cancer cells abrogates their tumor-associated osteoclastogenic activity, impairing osseous colonization. This study unveils the role played by the C5a/C5aR1 axis in lung cancer dissemination and supports its potential use as a novel therapeutic target.
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