车身平面图
斑马鱼
侧板中胚层
中胚层
不对称
生物
节的
细胞生物学
解剖
神经科学
脊椎动物
遗传学
胚胎干细胞
胚胎
基因
物理
量子力学
作者
Takaaki Matsui,Yasumasa Bessho
标识
DOI:10.1007/s00018-012-0985-6
摘要
In vertebrates, internal organs are positioned asymmetrically across the left-right (LR) axis, placing them in a defined area within the body. This LR asymmetric placement is a conserved feature of the vertebrate body plan. Events determining LR asymmetry occur during embryonic development, and are regulated by the coordinated action of genetic mechanisms that are evolutionarily conserved among vertebrates. Recent studies using zebrafish have provided new insights into how the Kupffer's vesicle organizer region is generated, and how it relays LR asymmetry information to the lateral plate mesoderm. In this review, we summarize recent advances in zebrafish and describe our current understanding of the mechanisms underlying these processes.
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