杜仲
CD80
化学
多糖
半乳糖
CD86
单糖
免疫刺激剂
岩藻糖
生物化学
体内
阿拉伯糖
CD40
体外
生物
免疫学
免疫系统
木糖
发酵
细胞毒性T细胞
替代医学
医学
基因
中医药
生物技术
病理
表型
作者
Haibo Feng,Jing Fan,Zhenhui Song,Xiaogang Du,Ying Chen,Jishuang Wang,Guodong Song
标识
DOI:10.1016/j.carbpol.2015.09.079
摘要
The aim of this study is to investigate the physicochemical properties, monosaccharide composition and immunomodulatory effects of Eucommia ulmoides Oliv. polysaccharide. The average molecular weight (Mw) of EUPS was 11.4632 × 105 Da. The monosaccharide components of EUPS were glucose, fructose, mannose, fucose, galactose and arabinose with a relative mass of 36.6%, 16.6%, 14.2%, 15.7%, 9.5% and 7.4%, respectively. In in vitro experiments, EUPS (1.2–75 μg/mL) treatment of dendritic cells (DC) increased their surface expression of MHC I/II, CD80, CD40, and CD86 and indicated that EUPS induced DC maturation. Furthermore, EUPS also significantly enhanced lymphocyte proliferation and significantly enhanced cytokine (IL-4 and IFN-γ) production. In in vivo experiments, our data showed that EUPS could significantly enhance the FMDV-specific IgG, IgG1, IgG2a, and IgG2b antibody titers and T cell proliferation. Together, these results suggest that EUPS is a strong immunostimulant.
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