趋化性
胶原酶
体外
三肽
羟脯氨酸
化学
生物化学
成纤维细胞
Ⅰ型胶原
分子生物学
细胞生物学
炎症
肽
生物
免疫学
酶
内分泌学
受体
作者
Arnold E. Postlethwaite,Jerome M. Seyer,Andrew H. Kang
标识
DOI:10.1073/pnas.75.2.871
摘要
The chemotactice response of human dermal fibroblasts of type I, II, and III human collagens and collagen-derived peptides was quantitated by an in vitro assay. All three native human collagens and constituent alpha chains can serve as chemoattractants for fibroblasts in vitro. When type I, II, and III collagens were digested by bacterial collagenase, the resulting peptides were also chemotactic. In addition, synthetic di- and tripeptides containing hydroxyproline were also chemotactic for fibroblasts. Since collagen is degraded and remodeled at sites of tissue injury and inflammation, these findings suggest that collagen and collagen-degradation peptides might function as chemotactic stimuli for fibroblasts in vivo and attract these cells to effect repair of damaged tissue.
科研通智能强力驱动
Strongly Powered by AbleSci AI