A Classification of Hashimoto's Thyroiditis Based on Immunohistochemistry for IgG4 and IgG

Our study indicates that HT can be divided into IgG4-positive and IgG4-negative HT, and this classification might have important clinical implications. The levels of IgG4 binding to specific thyroid antigens might be noninvasive markers to differentiate these two different immunophenotypes.