Scientists are very interested in because it gives a much better understanding of an organism than genomics. First, the level of transcription of a gene gives only a rough estimate of its level of expression into a protein. Whole Genome Sequence gives complete proteins contain, but does not show how proteins function or biological processes occur. Proteomics gives large-scale study of proteins, particularly their structures and functions. Proteomics is a term in the study of genetics which refers to all the proteins expressed by a genome; involves the identification of proteins in the body and the determination of their role in physiological and pathphysiological functions. The term proteomics was coined to make an analogy with genomics, the study of the genes. The word proteome is a blend of and genome. Proteomics technologies are of major three types Expression Proteomics, Structural Proteomics, Functional Proteomics. Proteomics is applied in various fields like Tumor Metastasis, renal disease diagnosis, Neurology etc. But proteomic technologies hold great promise in the search for clinically useful protein biomarkers for the early detection, diagnosis and prognosis of cancer and for monitoring response to therapy.