脂蛋白脂酶
脂解
脂肪组织
脂质代谢
生物
基因亚型
脂肪酶
肝脂肪酶
酶
细胞生物学
内分泌学
生物化学
基因
作者
Yuan Li,Ping He,Da Wei Zhang,Xi-Long Zheng,Fracisco S. Cayabyab,Wang Yin,Chao-Ke Tang
标识
DOI:10.1016/j.atherosclerosis.2014.10.016
摘要
Lipoprotein lipase (LPL) is a key enzyme in lipid metabolism and responsible for catalyzing lipolysis of triglycerides in lipoproteins. LPL is produced mainly in adipose tissue, skeletal and heart muscle, as well as in macrophage and other tissues. After synthesized, it is secreted and translocated to the vascular lumen. LPL expression and activity are regulated by a variety of factors, such as transcription factors, interactive proteins and nutritional state through complicated mechanisms. LPL with different distributions may exert distinct functions and have diverse roles in human health and disease with close association with atherosclerosis. It may pose a pro-atherogenic or an anti-atherogenic effect depending on its locations. In this review, we will discuss its gene, protein, synthesis, transportation and biological functions, and then focus on its regulation and relationship with atherosclerosis and potential underlying mechanisms. The goal of this review is to provide basic information and novel insight for further studies and therapeutic targets.
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