逆转录病毒
病毒学
核糖核酸
体外
人类免疫缺陷病毒(HIV)
二聚体
细胞质
化学
生物
作者
Ioulia Rouzina,Orlando Guzman,Robijn Bruinsma
标识
DOI:10.1016/j.bpj.2021.11.1685
摘要
Human immunodeficiency retrovirus (HIV-1) is known to package its full length viral RNA (vRNA) dimer with exceptionally high >90% selectivity, despite of the extremely low () fraction of vRNA in the cytoplasm of infected cell. While ∼150nt-long packaging signal (Psi) of HIV-1 vRNA was identified, no strong Gag binding preference sufficient of vRNA selective packaging was ever observed either in vitro or in cells. We propose kinetic model of selective HIV-1 vRNA dimer packaging based on extensive body of available experimental data.
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