Functional oligosaccharide fermentation in the gut: Improving intestinal health and its determinant factors-A review

The human intestine is characterized by an abundance of nutrients and a complex microbiota that make crucial contributions to overall health. These nutrients facilitate the adaptation of resident commensals to extreme environments and the development of a robust ecological network in host species. Long-term deprivation of microbiota-accessible carbohydrates (MACs) in the gut results in a loss of bacterial diversity, disruption of intestinal barrier function, and inflammatory diseases. Functional oligosaccharides are excellent MACs possessing important prebiotic properties for intestinal health through their fermentation in the gut. Its mechanism of action is predominantly attributed to acting as carbon sources for specific probiotics, promoting short-chain fatty acids production, and regulating the gut microbiota. In this review, we describe the source and structural characteristics of functional oligosaccharides, provide a framework for strategies to improve intestinal health by oligosaccharide fermentation and discuss structural determinants influencing the functional properties of oligosaccharides.