X射线光电子能谱
接触角
灭菌(经济)
润湿
聚合物
烯烃纤维
表面粗糙度
共聚物
原子力显微镜
材料科学
化学工程
核化学
高分子化学
化学
分析化学(期刊)
有机化学
纳米技术
复合材料
货币经济学
工程类
经济
外汇市场
外汇
作者
Hala Barakat,Johanna Saunier,C. Aymes Chodur,P. Aubert,Jackie Vigneron,Arnaud Etchéberry,Najet Yagoubi
标识
DOI:10.1016/j.ijpharm.2013.07.065
摘要
A cyclo-olefin copolymer was subjected to an e-beam ionizing treatment. Two doses were studied: one corresponding to the recommended dose for the sterilization of pharmaceutical packaging (25 kGy), and a greater one to enhance the modifications caused by the treatment (150 kGy). The surface modifications were studied by X-ray photoelectron spectroscopy (XPS), contact angle measurements and atomic force microscopy (AFM). The roughness and the wettability of the surface were enhanced by the treatment. The consequences of the surface modifications on the drug interaction with the polymer were studied.
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