医学
孟德尔随机化
冲程(发动机)
神经影像学
胼胝体
样本量测定
脑出血
部分各向异性
内科学
磁共振弥散成像
磁共振成像
生物信息学
病理
放射科
遗传学
基因
精神科
基因型
机械工程
统计
数学
遗传变异
蛛网膜下腔出血
工程类
生物
作者
Ke Yu,Xiaofeng Chen,Jing Guo,Sen Wang,Xiaoting Huang,Yan Guo,Shanshan Dong,Tie‐Lin Yang
出处
期刊:BMC Medicine
[Springer Nature]
日期:2023-07-25
卷期号:21 (1)
标识
DOI:10.1186/s12916-023-02982-9
摘要
Abstract Background Stroke is a major cause of mortality and long-term disability worldwide. Whether the associations between brain imaging-derived phenotypes (IDPs) and stroke are causal is uncertain. Methods We performed two-sample bidirectional Mendelian randomization (MR) analyses to explore the causal associations between IDPs and stroke. Summary data of 587 brain IDPs (up to 33,224 individuals) from the UK Biobank and five stroke types (sample size range from 301,663 to 446,696, case number range from 5,386 to 40,585) from the MEGASTROKE consortium were used. Results Forward MR indicated 14 IDPs belong to projection fibers or association fibers were associated with stroke. For example, higher genetically determined mean diffusivity (MD) in the right external capsule was causally associated with an increased risk of small vessel stroke (IVW OR = 2.76, 95% CI 2.07 to 3.68, P = 5.87 × 10 −12 ). Reverse MR indicated that genetically determined higher risk of any ischemic stroke was associated with increased isotropic or free water volume fraction (ISOVF) in body of corpus callosum (IVW β = 0.23, 95% CI 0.14 to 0.33, P = 3.22 × 10 −7 ). This IDP is a commissural fiber and it is not included in the IDPs identified by forward MR. Conclusions We identified 14 IDPs with statistically significant evidence of causal effects on stroke or stroke subtypes. We also identified potential causal effects of stroke on one IDP of commissural fiber. These findings might guide further work toward identifying preventative strategies at the brain imaging levels.
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