先天性淋巴细胞
免疫学
嗜酸性粒细胞增多症
先天免疫系统
脱敏(药物)
肺
免疫系统
过敏
生物
受体
医学
内科学
作者
Katharine E. Block,Koji Izutsu,Mark Pierson,Daniel Walsh,Rinna Tei,Tamara A. Kucaba,Julie Xu,Mohammad Haneef Khan,Christopher Staley,Thomas S. Griffith,Henry J. McSorley,Hirohito Kita,Stephen C. Jameson
出处
期刊:Nature Immunology
[Springer Nature]
日期:2022-11-21
卷期号:23 (12): 1703-1713
被引量:10
标识
DOI:10.1038/s41590-022-01350-8
摘要
Lung group 2 innate lymphoid cells (ILC2s) control the nature of immune responses to airway allergens. Some microbial products, including those that stimulate interferons, block ILC2 activation, but whether this occurs after natural infections or causes durable ILC2 inhibition is unclear. In the present study, we cohoused laboratory and pet store mice as a model of physiological microbial exposure. Laboratory mice cohoused for 2 weeks had impaired ILC2 responses and reduced lung eosinophilia to intranasal allergens, whereas these responses were restored in mice cohoused for ≥2 months. ILC2 inhibition at 2 weeks correlated with increased interferon receptor signaling, which waned by 2 months of cohousing. Reinduction of interferons in 2-month cohoused mice blocked ILC2 activation. These findings suggest that ILC2s respond dynamically to environmental cues and that microbial exposures do not control long-term desensitization of innate type 2 responses to allergens.
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