[Research Progress of Next Generation Sequencing in Acute Leukemia --Review].

With the advent of precision medicine, next-generation sequencing (NGS) is playing an increasingly important role in clinical oncology diagnosis and treatment with its advantages of high sensitivity, high accuracy, high efficiency and operability. NGS reveals the genetic characteristics of acute leukemia(AL) patients by screening for specific disease-causing genes to identify occult as well as complex genetic mutations in patients with AL, leading to early diagnosis and targeted drug therapy for AL patients, as well as to predict disease recurrence by detecting mnimal residual disease (MRD) and analyzing mutated genes to determine patient prognosis. NGS plays an increasingly important role in the diagnosis, treatment and prognosis assessment in AL, providing a direction for the pursuit of precision medicine. This paper reviews the research progress of NGS in AL.二代测序在急性白血病中的研究进展..随着精准医疗时代的到来，二代测序（next-generation sequencing, NGS）以其高灵敏度、高精确度、高效性以及可操作性的优势，在临床肿瘤诊疗过程中发挥着越来越重要的作用。NGS通过对特定的致病基因筛查，可发现急性白血病（AL）患者中隐匿性以及复杂性的基因突变，揭示AL患者的遗传学特点，从而对AL患者进行早期诊断，靶向药物治疗，还可以通过检测MRD，预测疾病的复发，分析突变基因判断患者的预后。NGS在AL中的诊断、治疗以及预后评估中发挥着越来越重要的作用，为追求精准医疗提供了方向。本文将围绕NGS在AL中的最新研究进展作一综述。.