医学
导管癌
乳腺癌
阶段(地层学)
内科学
病态的
肿瘤科
雌激素受体
相关性
癌症
病理
古生物学
几何学
数学
生物
作者
Zijing Zhang,Hongying Wang,Yonglong Jin,Jian Zhou,Chia‐Ching Chu,Feng Tang,Li‐Ping Zou,Qiang Zou
出处
期刊:Biomarkers in Medicine
[Future Medicine]
日期:2023-06-01
卷期号:17 (12): 553-562
被引量:1
标识
DOI:10.2217/bmm-2023-0130
摘要
Objective: This study was designed to explore KRT15 dysregulation and its correlation with clinical characteristics among ductal carcinoma in situ (DCIS), DCIS with microinvasion (DCIS-MI) and invasive breast cancer (IBC) patients. Methods: KRT15 from lesion samples of 50 DCIS patients, 48 DCIS-MI patients and 50 IBC patients was detected by immunohistochemistry. Results:KRT15 discriminated IBC patients from DCIS patients (area under the curve [AUC] = 0.895; 95% CI = 0.836-0.954) and DCIS-MI patients (AUC = 0.707; 95% CI = 0.606-0.808). In DCIS patients, KRT15 was negatively correlated with pathological grade (p = 0.015). In DCIS-MI patients, KRT15 was positively related to estrogen receptor positivity but negatively associated with Ki-67 (both p < 0.05). In IBC patients, KRT15 was negatively linked to HER2 positivity, histological grade, N stage and tumor node metastasis stage (all p < 0.05). Conclusion:KRT15 assessment may help with early breast cancer screening.
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