邻苯二甲酸盐
TLR4型
神经退行性变
毒性
神经毒性
神经肽Y受体
内分泌学
促炎细胞因子
内科学
医学
神经肽
药理学
化学
炎症
受体
疾病
有机化学
作者
Mhasen Khalifa,R.H. Fayed,Ahmad A. Sedik,Heba M. A. Khalil
标识
DOI:10.1016/j.taap.2023.116515
摘要
Di -(2-ethylhexyl) phthalate (DEHP) is a widely used phthalate that possesses a public health concern. Different concentrations of DEHP, including 50, 300, and 750 mg/kg were administrated orally for 28 days in male rats. Body weight and vital organs weight were measured as well as anxiety-like behavior, short and long-term memory were investigated. Brain inflammatory cytokines, including IL-1β, TLR4, NF-κB, TNF-α, and IL1–6 were assessed. Brain caspase-3, neuropeptide-Y (NPY), and brain histopathology were also evaluated. DEHP triggers the release of pro-inflammatory cytokines via inducing the nuclear translocation of the signaling pathway; TLR 4/ NF-κB leads to cognitive impairment and neurodegeneration, which is confirmed by the impaired brain architecture. Also, DEHP upgrades the expression levels of brain caspase-3 and NPY. In conclusion, exposure to high doses of DEHP persuades great toxicity visualized by behavioral, biochemical, and histological impairments when compared to the low doses.
科研通智能强力驱动
Strongly Powered by AbleSci AI