Continuous Flow Catalytic Reductive Amination of Carbonyl Compounds to Primary Amines with Carbon‐Coated Co@CS Catalyst under Mild Conditions

Reductive amination is crucial for synthesizing amines in pharmaceutical and industry, yet selectively producing primary amines on a large scale remains challenging. This work presents a continuous‐flow reductive amination process using benzaldehyde with NH 3 and H 2 as the nitrogen sources and reductant. A cobalt catalyst supported on nitrogen‐doped carbon derived from chitosan (Co@CS) was developed. After optimization, a primary amine yield exceeding 99% was achieved under mild reaction conditions. The catalyst demonstrated excellent stability in long‐term tests and with various substrates, including the biomass lignin‐derived vanillin. Compared to batch reactors, theflow reactor provided superior selectivity. This catalytic flow process minimizes waste, enhances atom economy, avoids hazardous chemical, and improves energy efficiency. The use of a renewable chitosan feedstock and a safer process aligns with multiple principles of green chemistry. The exceptional heat and mass transfer in the Flow system offers an effective strategy for the large‐scale production of primary amines from biomass platform compounds.