PSMA Targeted Ligands in Imaging and Theranostics for Prostate Cancer

Prostate cancer (PCa) is the second most common type of cancer in men.Compared with conventional imaging methods, prostate-specific membrane antigen (PSMA)-targeted positron emission tomography has higher accuracy and specificity for the detection and treatment of PCa.Through targeted imaging, ligands are labelled with 18 F, 68 Ga, or 64 Cu, and the disease is staged and managed more accurately.It is also desirable to use PSMA-targeted theranostics that are labelled with either imaging radioisotopes or treatment isotopes such as 177 Lu, 225 Ac, 131 I. Here, we summarized some of the commonly used small molecule PSMA ligands for imaging and theranostic purposes.