Review of synthesis process of benzimidazole-heterocycle hybrid compounds

Over the last few years, benzimidazole-heterocycle hybrid compounds have received considerable attention due to the wide spectrum of their biological property and many important chemical and pharmacological applications. These compounds have revealed antibacterial, antimicrobial, anticoagulant, antidiabetic and other activities, and they have been used as drugs in the market to treat several diseases. Furthermore, hybrid heterocyclic compounds possessing a benzimidazole skeleton exhibit significant complexing and anticorrosive properties. All of these applications have favored the development of a large number of synthetic strategies to prepare these heterocyclic systems in different reaction conditions. Many research articles on the synthesis of benzimidazole-heterocycle hybrid compounds have been reported in the literature. In this review, we present and discuss the synthetic routes of several benzimidazole-heterocycle hybrid compounds.