A Case Report

Prostate-specific membrane antigen (PSMA) PET/CT scan has significantly improved the detection and staging of prostate cancer. We report a rare case of a 72-year-old man with a history of Gleason score 7 (3 + 4) prostate adenocarcinoma, status post radical prostatectomy, referred for restaging PSMA PET/CT scan due to rising PSA (0.12 μg/L). The scan revealed a PSMA-avid lesion in the retroperitoneum, later confirmed via further investigations and histopathological analysis to be a retroperitoneal hemangioma. This case emphasizes the challenges in interpreting PSMA PET/CT scan in prostate cancer and highlights the significance of thorough consideration in forming a comprehensive differential diagnosis.