Trametinib as a promising therapy for Darier disease: case report

Darier disease (DD) is a rare autosomal-dominant genodermatosis caused by mutations in the ATP2A2 gene, which encodes sarco-endoplasmic reticulum calcium ATPase 2 (SERCA2). This leads to impaired intercellular adhesion and epidermal blistering. We report the case of a 25-year-old man with severe DD who demonstrated a positive response to trametinib after multiple unsuccessful therapies.