伪麻黄碱
色谱法
麻黄素
毛细管电泳
化学
右美沙芬
鼻减充血剂
分析物
校准曲线
检出限
马来酸氯苯那敏
药理学
麻醉
医学
作者
Beytul Yener,Cem Erkmen,Bengi Uslu,Nilgün Günden Göğer
出处
期刊:Brazilian Journal of Pharmaceutical Sciences
[SciELO]
日期:2022-01-01
卷期号:58
标识
DOI:10.1590/s2175-97902022e19836
摘要
A capillary electrophoresis method was developed for the first time and optimized for the determination of paracetamol, pseudoephedrine, dextromethorphan, chlorpheniramine, 4-aminophenol and ephedrine in tablet formulation.Optimum electrophoretic conditions were achieved by using a background electrolyte of 75 mmol L -1 sodium borate buffer at pH 8.0, a capillary temperature of 30°C, a separation voltage of 30 kV and a pressure injection of the sample at 50 mbar for 10 s.Calibration graphs showed a good linearity with a coefficient of determination (R 2 ) of at least 0.999 for all compounds.Intraday and interday precision (expressed as relative standard deviation (RSD) %) were lower than 1.39% for capillary electrophoresis method.The developed method was demonstrated to be simple and rapid for the determination of paracetamol, pseudoephedrine, dextromethorphan, chlorpheniramine, 4-aminophenol and ephedrine in tablet formulation providing recoveries in the range between 99.62 and 100.57% for all analytes.
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