The combined effect of epidermal growth factor and keratinocyte growth factor delivered by hyaluronic acid hydrogel on corneal wound healing

This study strategically combines epidermal growth factor (EGF) and keratinocyte growth factor (KGF) within a hyaluronic acid (HA) hydrogel to enhance corneal wound healing. The controlled release of EGF and KGF from the HA hydrogel is carefully designed to enhance the regeneration of both the epithelial and stromal layers. Specifically, EGF plays a critical role in the regeneration of the epithelial layer, while KGF shows efficacy in the regeneration of the stromal layer. The combination of these factors not only promotes efficient regeneration of each layer but also demonstrates the ability to effectively modulate each other's regenerative effects. This nuanced interplay between EGF and KGF provides a comprehensive understanding of their cooperative influence on the dynamics of corneal wound healing.