材料科学
生物污染
抗菌剂
生物相容性材料
制作
纳米技术
固化(化学)
药品
医疗器械
生物医学工程
复合材料
有机化学
膜
化学
生物化学
医学
精神科
病理
心理学
替代医学
作者
Lisheng Wang,S. Gopalakrishnan,David C. Luther,Vincent M. Rotello
标识
DOI:10.1021/acsami.1c15001
摘要
Nosocomial infections, caused by bacterial contamination of medical devices and implants, are a serious healthcare concern. We demonstrate here, the use of fluorous-cured protein nanofilm coatings for generating antimicrobial surfaces. In this approach, bacteria-repelling films are created by heat-curing proteins in fluorous media. These films are then loaded with antibiotics, with release controlled via electrostatic interactions between therapeutic and protein film building blocks to provide bactericidal surfaces. This film fabrication process is additive-free, biocompatible, biodegradable, and can be used to provide antimicrobial coatings for both three-dimensional (2D) and 3D objects for use in indwelling devices.
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