Age and seasonal variation and establishment of reference intervals for water-soluble vitamins determined by liquid chromatography tandem mass spectrometry

For values obtained using liquid chromatography tandem mass spectrometry, the lower limits of reference intervals for vitamins B₁ (ages 15-100 y), B₂, B₃, B₇, and C should be lowered, that of vitamin B₅ should be raised, and the upper limits of reference intervals for vitamins B₁, B₃, B₅, B₆, and B₇ should be lowered.