乳状液
微乳液
药物输送
溶解度
生化工程
药品
纳米技术
计算机科学
化学
工艺工程
材料科学
药理学
有机化学
工程类
医学
肺表面活性物质
生物化学
作者
Daisuke Mori,Poonam Vaghela,Kajal S. Patel,Keshvi Sojitra,Mohini Patel,Sushma Patel,Kiran Dudhat,Sunny Shah,Ravi Manek,Ramesh Parmar
标识
DOI:10.1007/s13346-021-01071-9
摘要
Lipid-based emulsion system - a subcategory of emulsion technology, has emerged as an enticing option to improve the solubility of the steadily rising water-insoluble candidates. Along with enhancing solubility, additional advantages such as improvement in permeability, protection against pre-systemic metabolism, ease of manufacturing, and easy to scale-up have made lipid-based emulsion technology very popular among academicians and manufacturers. The present article provides a comprehensive review regarding various critical properties of lipid-based emulsion systems, such as microemulsion, nanoemulsion, SMEDDS (self microemulsifying drug delivery system), and SNEDDS (self nanoemulsifying drug delivery system). The present article also explains in detail the similarities and differences between them, the stabilization mechanism, methods of preparation, excipients used to prepare them, and evaluation techniques. Subtle differences between nearly related terminologies such as microemulsion and nanoemulsion, SMEDDS, and SNEDDS are also explained in detail to clarify the basic differences. The present article also gives in-depth information regarding the chemical structure of various lipidic excipients, various possible chemical modifications to modify their inherent properties, and their regulatory status for rational selection.
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