生物
先天免疫系统
获得性免疫系统
巨噬细胞
免疫学
免疫
免疫系统
微生物学
非结核分枝杆菌
肺结核
吞噬体
吞噬作用
分枝杆菌
细菌
医学
体外
病理
生物化学
遗传学
作者
Masoud Shamaei,Mehdi Mirsaeidi
摘要
Although nontuberculous mycobacteria (NTM) are considered opportunistic infections, incidence and prevalence of NTM infection are increasing worldwide becoming a major public health threat. Innate immunity plays an essential role in mediating the initial host response against these intracellular bacteria. Specifically, macrophages phagocytose and eliminate NTM and act as antigen-presenting cells, which trigger downstream activation of cellular and humoral adaptive immune responses. Identification of macrophage receptors, mycobacterial ligands, phagosome maturation, autophagy/necrosis, and escape mechanisms are important components of this immunity network. The role of the macrophage in mycobacterial disease has mainly been studied in tuberculosis (TB), but limited information exists on its role in NTM. In this review, we focus on NTM immunity, the role of macrophages, and host interaction in NTM infection.
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