结核分枝杆菌
蛋白质酪氨酸磷酸酶
生物
磷酸酶
激酶
信号转导
细胞生物学
肺结核
磷酸化
微生物学
医学
病理
作者
Joseph D. Chao,Dennis Wong,Xingji Zheng,Valérie J. Poirier,Horacio Bach,Zakaria Hmama,Yossef Av‐Gay
标识
DOI:10.1016/j.bbapap.2009.09.008
摘要
Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), evades the antimicrobial defenses of the host and survives within the infected individual through a complex set of strategies. These include active prevention of host cellular killing processes as well as overwhelming adaptive gene expression. In the past decade, we have gained an increased understanding of how mycobacteria not only have the ability to adapt to a changing host environment but also actively interfere with the signaling machinery within the host cell to counteract or inhibit parts of the killing apparatus employed by the macrophage. Mtb is able to sense its environment via a set of phospho-signaling proteins which mediate its response and interaction with the host in a coordinated manner. In this review, we summarize the current knowledge about selected Mtb serine, threonine, and tyrosine kinase and phosphatase signaling proteins, focusing on the protein kinases, PknG and PtkA, and the protein phosphatase, PtpA.
科研通智能强力驱动
Strongly Powered by AbleSci AI