顺铂
铂金
铂化合物
化学
组合化学
药理学
限制
药品
医学
化疗
生物化学
内科学
催化作用
机械工程
工程类
作者
Miguel A. Fuertes,Josefina Castilla,Carlos Alonso,José Antonio López Pérez
出处
期刊:Current medicinal chemistry
[Bentham Science]
日期:2002-07-01
卷期号:2 (4): 539-551
被引量:89
标识
DOI:10.2174/1568011023353958
摘要
The limitations of cisplatin as an anticancer drug have stimulated the search for other antitumor-active platinum complexes with improved pharmacological properties. The two main goals in the search for new platinum anti-cancer agents are the reduction of the dose-limiting toxicities of cisplatin and the circumvention of cisplatin resistance. However, it should be pointed out that this has proven to be a difficult task. In fact, less than 1% of the thousand of platinum complexes tested for pre-clinical antitumor activity have entered clinical trials in the past 30 years. Nonetheless, right now, several new platinum complexes are in clinical trials, a proof of the continued belief that platinum complexes may still fulfil the needs for novel antitumor drugs. This review will focus on the three main innovative approaches found in the platinum anticancer-field, namely, (1) compounds with decreased reactivity against nucleophiles, (2) compounds with carrier ligands, and (3) compounds which bind differently to DNA as compared to cisplatin. In the latter class, special attention is paid to dinuclear and polinuclear platinum complexes.
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