化学
细胞毒性
组合化学
立体化学
生物化学
体外
作者
Chris L. Carroll,Jennifer V. C. Johnston,Ahmet Kekec,Julia Brown,Emily Parry,Julia Cajica,Irene Medina,Kristina M. Cook,Ricardo S. Corral,Po‐Shen Pan,Shelli R. McAlpine
出处
期刊:Organic Letters
[American Chemical Society]
日期:2005-07-08
卷期号:7 (16): 3481-3484
被引量:33
摘要
Described are the syntheses of 14 derivatives of the natural product Sansalvamide A, where two are more active against HCT 116 colon cancer cell lines than the natural product. These derivatives were synthesized using a combinatorial-type strategy that permits elucidation of the amino acid role in the cytotoxicity, and they lay the groundwork for development of new anticancer agents. [structure: see text]
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