Preparation and Testing of Polylactic Acid Ultra Thin Fiber Membrane as the Sustained Release Material

In his paper, polylactic acid ultra- thin fibers membrane carried rifampicin were prepared by electrospinning technology, and release experiment of polylactic acid super thin fiber membrane with rifampicin were carried out in PBS solution. The resulted ultra-fine fibers membrane of polylactic acid membrane were characterized through scanning electron microscopy to decided the morphology, the results showed that the drug-loaded polylactic acid membrane contained microfiber in a range of 1μm-8μm in diameter; polylactic acid fiber diameter distribution was affected by molecular weight of polylactic acid, concentration of polylactic acid, quantity of drug loaded and spinning parameters such as voltage, the average fiber diameter increased when improved the mass fraction of PLA solution, the diameter of PLA ultra-fine fibers loaded rifampicin was thiner than PLA ultra-fine fibers. The performance of controlled release in phosphate buffer solution (PBS) was detected by UV, and their delivery rate was calculated by the detected result. The sustained release effect of polylactic acid Molecular with weight of 150,000 loaded rifampicin was better than polylactic acid ultra-fine fibers with the molecular weight of 100,000, the addition of lipase can improve release rate of rifampicin.