NICKEL–PHOSPHINE COMPLEX CATALYZED GRIGNARD SYNTHESIS OF STERICALLY HINDERED, UNSYMMETRICAL BIARYLS: AN APPROACH TO THE ASYMMETRIC SYNTHESIS OF BIARYL ATROPISOMERS

Abstract Sterically hindered, unsymmetrical biaryls can be prepared by the cross-coupling reaction of ortho-substituted aryl Grignard reagents with aryl halides in the presence of nickel–phosphine complexes as catalysts. Asymmetric synthesis of biaryl atropisomers has been accomplished with a chiral phosphine-nickel catalyst.