医学
喉
头颈部癌
放射治疗
头颈部
肿瘤科
临床试验
化疗
癌症
基底细胞
头颈部鳞状细胞癌
内科学
外科
作者
John D. Cramer,Barbara Burtness,Quynh‐Thu Le,Robert L. Ferris
标识
DOI:10.1038/s41571-019-0227-z
摘要
Head and neck cancers are a heterogeneous collection of malignancies of the upper aerodigestive tract, salivary glands and thyroid. In this Review, we primarily focus on the changing therapeutic landscape of head and neck squamous cell carcinomas (HNSCCs) that can arise in the oral cavity, oropharynx, hypopharynx and larynx. We highlight developments in surgical and non-surgical therapies (mainly involving the combination of radiotherapy and chemotherapy), outlining how these treatments are being used in the current era of widespread testing for the presence of human papillomavirus infection in patients with HNSCC. Finally, we describe the clinical trials that led to the approval of the first immunotherapeutic agents for HNSCC, and discuss the development of strategies to decrease the toxicity of different treatment modalities.
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