Catalyst free Synthesis of Highly Functionalized Indolizines from In Situ Generated Pyridinium Ylides via One‐Pot Multicomponent Reaction

Abstract A base‐promoted one‐pot three‐component domino reaction of in situ generated pyridinium ylides with α ‐oxoketene dithioacetals (AKDTAs) lead to synthesis of indolizine derivatives. In this one‐pot transformation, three new bonds and one new ring was efficiently formed in one sequence. The current method provides a simple, convenient route for the synthesis of biologically important indolizine derivatives without using any catalyst in good yield. The synthesized compound 4 g was confirmed by single crystal X‐ray analysis.